Proinflammatory mediators stimulate neutrophil-directed angiogenesis.

  title={Proinflammatory mediators stimulate neutrophil-directed angiogenesis.},
  author={Matthew McCourt and Jian Wang and Shastri Sookhai and Henry Paul Redmond},
  journal={Archives of surgery},
  volume={134 12},
  pages={1325-31; discussion 1331-2}
BACKGROUND Vascular endothelial growth factor (VEGF; vascular permeability factor) is one of the most potent proangiogenic cytokines, and it plays a central role in mediating the process of angiogenesis or new blood vessel formation. Neutrophils (PMNs) recently have been shown to produce VEGF. HYPOTHESIS The acute inflammatory response is a potent stimulus for PMN-directed angiogenesis. METHODS Neutrophils were isolated from healthy volunteers and stimulated with lipopolysaccharide (LPS… CONTINUE READING


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Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) enhance lipopolysaccharide binding to neutrophils via CD14.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] • 1998
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