Proinflammatory functions of vascular endothelial growth factor in alloimmunity.

@article{Reinders2003ProinflammatoryFO,
  title={Proinflammatory functions of vascular endothelial growth factor in alloimmunity.},
  author={Marlies E J Reinders and Masayuki Sho and Atsushi Izawa and Ping Wang and Debabrata Mukhopadhyay and Kerith E Koss and Christopher S. Geehan and Andrew D Luster and Mohamed H. Sayegh and David Michael Briscoe},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={112 11},
  pages={
          1655-65
        }
}
Vascular endothelial growth factor (VEGF), an established angiogenesis factor, is expressed in allografts undergoing rejection, but its function in the rejection process has not been defined. Here, we initially determined that VEGF is functional in the trafficking of human T cells into skin allografts in vivo in the humanized SCID mouse. In vitro, we found that VEGF enhanced endothelial cell expression of the chemokines monocyte chemoattractant protein 1 and IL-8, and in combination with IFN… CONTINUE READING

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