Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue.

@article{Cardier2005ProinflammatoryFP,
  title={Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue.},
  author={Jose E. Cardier and Eliana Mari{\~n}o and Egidio Romano and Peter R. Taylor and Ferdinando Liprandi and Norma B. de Bosch and Alan L Rothman},
  journal={Cytokine},
  year={2005},
  volume={30 6},
  pages={359-65}
}
There is evidence that severe dengue disease is associated with alterations of the microvascular endothelium. We examined the hypothesis that activation and damage of microvascular endothelial cells (EC) could be induced by inflammatory mediators present in dengue patient's sera. We cultured human microvascular EC (HMEC-1) in vitro with sera from patients with acute dengue infection. Sera from patients with acute dengue induced an increase in ICAM-1 expression on HMEC-1. This effect was greater… CONTINUE READING
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