Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative.

@article{Daniel2000ProinflammatoryEI,
  title={Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative.},
  author={Christoph Daniel and R Ziswiler and Bernhard Frey and Marc Pfister and Hans Peter Marti},
  journal={Experimental nephrology},
  year={2000},
  volume={8 1},
  pages={52-62}
}
BACKGROUND/AIM The new immunosuppressant SDZ RAD, a rapamycin derivative, inhibits growth factor driven cell proliferation. SDZ RAD designed for transplantation may also be a candidate agent to treat inflammatory kidney diseases. Therefore, we investigated the effects of SDZ RAD in two different animal models of glomerulonephritis, in anti- Thy1.1 nephritis and in acute puromycin aminonucleoside (PAN) nephrosis. METHODS Eighty-seven male Wistar rats were investigated. Anti-Thy1.1 nephritis… CONTINUE READING