Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

  title={Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization},
  author={Tong Xiao and Zhu Yan and Shengxiang Xiao and Yumin Xia},
  journal={Stem Cell Research \& Therapy},
The skin, which serves as the first barrier of the human body, is particularly susceptible to exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are commonly observed in clinics. Healing of skin wounds is a complex process, consisting of infiltration of inflammatory cells, cellular proliferation, and tissue remodeling phases, which restore the integrity and functions of the skin. Epithelialization is involved in wound healing through re-establishing an intact… Expand
Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts
This review focuses on the active participation of tissue-resident adipocytes and fibroblasts in pro-inflammatory signaling after injury, and how altered cellular communication from these cells can contribute to irregular inflammation associated with aberrant wound healing. Expand
Mesenchymal stem cells are prospective novel off-the-shelf wound management tools.
The therapeutic role played by MSCs and its secretome in suppressing tissue inflammation, causing immunomodulation, aiding angiogenesis and assisting in scar-free wound healing is outlined and its application as a futuristic technology for revolutionizing tissue regeneration is strongly advocated. Expand
Materials and Cytokines in the Healing of Diabetic Foot Ulcers
Key differences in native versus diabetic wound healing during each phase of healing are discussed, and the roles of cells and their secreted cytokines which regulate this process are outlined. Expand
Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity
Hydrogels containing high-sulfated hyaluronan/collagen as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing improved defective tissue repair with reduced inflammation, augmented pro-regenerative macrophages activation, increased vascularization, and accelerated new tissue formation and wound closure. Expand
Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells
  • Yuxi Jia, Xiangru Chen, Jing Sun
  • Medicine
  • Aging
  • 2021
Premilast might ameliorate IL-1α-induced dysfunction in ESCs by mitigating oxidative stress and inflammation through inhibiting the activation of the Myd88/TRAF6/NF-κB signaling pathway. Expand
Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway.
It is evidenced that ADSCs facilitate the increase in miR-29b andMiR-21 levels and promote the activation and proliferation of dermal fibroblasts and extracellular matrix (ECM) remodeling, with the associated release of VEGF. Expand
Xyloglucan and Concanavalin A based dressings in the topical treatment of mice wound healing process
Abstract For medical biomaterials, xyloglucan dispersions can form films or gels to be applied as a wound dressing. For this purpose, the structural characterization of xyloglucan dressing (XG) andExpand
Incorporation of grape seed extract towards wound care product development
The various phytochemical constituents found in grape seed extracts along with their mechanism of action that instigate wound healing are explored to encourage innovation scientists in the field to address current limitations and to effectively develop grape seed extract-based wound care product formulations for commercialization. Expand
In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potential
Results of the present study cumulatively revealed that the green synthesized FeTP ointment approach may serve as a potential tool for dermal wound healing. Expand
CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties
CD34+ McSCs may be useful for myelinating neurons in vivo, leading to new therapeutic opportunities for demyelinating diseases and traumatic nerve injury and genome-wide expression profiling results support the distinct nature of these populations. Expand


Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies.
This review summarizes the current knowledge regarding the management and treatment of acute and chronic wounds, with a focus on re-epithelialization, offering some insights into novel future therapies. Expand
Epidermal stem cells in wound healing and their clinical applications
The characteristics of EPSC and the mechanisms underlying their functions during wound healing are reviewed and applications of EPSCs are discussed to determine the potential and feasibility of using EPSCs clinically in wound healing. Expand
Proinflammatory Cytokines and Skin Wound Healing in Mice
Skin wound healing is subject to an intricate regulation, involves many cell populations and molecular mediators, and is one of the key mechanisms that ensures the barrier functions of the skin andExpand
Epidermal Stem Cells in Skin Wound Healing.
This review will dissect the biological process of adult skin wound healing and emphasize the importance of epidermal stem cells during the wound healing, including both traditional skin grafting procedures and advanced grafting techniques with cultured skin stem cells. Expand
Epithelialization in Wound Healing: A Comprehensive Review.
The pivotal role of keratinocytes in epithelialization is focused on, including cellular processes and mechanisms of their regulation during re-epithelialization, and their cross talk with other cell types participating in wound healing. Expand
Mesenchymal stem cell therapy for attenuation of scar formation during wound healing
Specific mechanisms by which mesenchymal stem cells can limit tissue fibrosis are identified and a summary of recent in vivo studies where these cells have been used successfully to limit scar formation is summarized. Expand
Skin tissue regeneration for burn injury
The essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment are described and the high efficacy and cost-effectiveness of each therapy are compared. Expand
Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration
Major treatment modalities currently available for the treatment of the wound, role of various interstitial stem cells and exogenous adult stem cells in cutaneous wound healing, and possible mechanisms involved in the healing process are emphasized. Expand
Topical TWEAK Accelerates Healing of Experimental Burn Wounds in Mice
Topical TWEAK exhibits therapeutic effect on experimental burn wounds through favoring regional inflammation, cytokine production, and extracellular matrix synthesis and induces the myofibroblastic differentiation of dermal fibroblasts, partially contributing to the healing of burn wounds. Expand
From Inflammation to Current and Alternative Therapies Involved in Wound Healing
The pathway in the skin healing cascade is reviewed, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency. Expand