Proinflammatory cytokines regulate Fc alphaR expression by human mesangial cells in vitro.

@article{Bagheri1997ProinflammatoryCR,
  title={Proinflammatory cytokines regulate Fc alphaR expression by human mesangial cells in vitro.},
  author={Nayer Bagheri and Subba Rao Chintalacharuvu and Steven Noel Emancipator},
  journal={Clinical and experimental immunology},
  year={1997},
  volume={107 2},
  pages={404-9}
}
IgA nephropathy (IgAN) is defined by the predominant deposition of IgA immune complexes (IC) in the glomerular mesangium. Interaction between IgA immune complexes and mesangial cells (MC) could be a linchpin for the genesis of IgAN. We studied the modulation of MC expression of IgA receptors (Fc alphaR) by selected cytokines. Binding of 125I-IgA to quiescent human MC showed 2.55 x 10(5) sites/cell with an affinity (Ka) of 3.2 x 10(7) M(-1). Addition of selected recombinant cytokines had no… CONTINUE READING

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