Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.

  title={Proinflammatory cytokines inhibit secretion in rat bile duct epithelium.},
  author={Carlo Spirl{\'i} and Michael H. Nathanson and Romina Fiorotto and Elena Duner and Lee A. Denson and Juana M. Sanz and Francesco Di Virgilio and Lajos Okolicsanyi and Francesca Casagrande and Mario Strazzabosco},
  volume={121 1},
BACKGROUND AND AIMS Cholestatic disorders often are associated with portal inflammation, but whether or how inflammation contributes to cholestasis is unknown. Thus we studied the effects of proinflammatory cytokines on bile duct epithelia secretory mechanisms. METHODS Isolated bile duct units (IBDUs) were cultured with interleukin (IL)-6, interferon gamma, tumor necrosis factor (TNF)-alpha, and IL-1 alone or in combination. Ductular secretion was measured using video-optical planimetry… CONTINUE READING


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