Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy.

@article{Herfs2012ProinflammatoryCI,
  title={Proinflammatory cytokines induce bronchial hyperplasia and squamous metaplasia in smokers: implications for chronic obstructive pulmonary disease therapy.},
  author={M Micha{\"e}l Herfs and Pascale Hubert and A L Poirrier and Patricia Vandevenne and Virginie M Renoux and Yvette Habraken and Didier Cataldo and Jacques Boniver and Philippe O Delvenne},
  journal={American journal of respiratory cell and molecular biology},
  year={2012},
  volume={47 1},
  pages={67-79}
}
Tracheobronchial squamous metaplasia is common in smokers, and is associated with both airway obstruction in chronic obstructive pulmonary disease (COPD) and increased risk of lung cancer. Although this reversible epithelial replacement is almost always observed in association with chronic inflammation, the role of inflammatory mediators in the pathogenesis… CONTINUE READING