Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells.

@article{Strong1998ProinflammatoryCD,
  title={Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells.},
  author={Scott A. Strong and Theresa Torres Pizarro and Jonathan D. S. Klein and Fabio Cominelli and Claudio Fiocchi},
  journal={Gastroenterology},
  year={1998},
  volume={114 6},
  pages={
          1244-56
        }
}
BACKGROUND & AIMS Intestinal homeostasis is coordinated through the response of different cell types, including the interaction of immune with nonimmune cells. This study investigated the effect of immune cell-derived proinflammatory cytokines on mesenchymal cell proliferation and gene product expression. METHODS Primary cultures of human mucosal mesenchymal cells were activated with interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha (TNF-alpha). Proliferation was measured by… CONTINUE READING
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