Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium.

@article{Dommergues2000ProinflammatoryCA,
  title={Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium.},
  author={M A Dommergues and Juliana Patkai and Jean Christophe Renauld and Philippe P Evrard and Pierre Gressens},
  journal={Annals of neurology},
  year={2000},
  volume={47 1},
  pages={54-63}
}
Many prenatal and perinatal factors are hypothesized to play a role in the cause of cerebral palsy (CP). Epidemiological data implicate maternal-fetal infection and associated increase in circulating cytokines. Murine model data suggest that excitotoxic damage can produce pathological change in brain tissue consistent with lesions observed in CP. Specifically, on day 5 after birth, mouse pups injected with ibotenate, a glutamatergic analogue, develop transcortical necrosis and white matter… CONTINUE READING

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