Proinflammatory cytokines and hemofiltration membranes.

  title={Proinflammatory cytokines and hemofiltration membranes.},
  author={Stanley Goldfarb and Thomas A. Golper},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={5 2},
To determine whether the clinical improvement noted in some septic patients undergoing hemofiltration is in part due to the removal of proinflammatory mediators, in vitro hemofiltration of a 1% albumin solution containing recombinant human tumor necrosis factor alpha and interleukin-1 was performed through a variety of hemofilters. Observed sieving coefficients of these cytokines was much higher (up to 0.35) than expected, considering their molecular weights of 17 kd. In addition, binding of up… CONTINUE READING

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