Proinflammatory cytokines and chemokines in humans with Japanese encephalitis.

  title={Proinflammatory cytokines and chemokines in humans with Japanese encephalitis.},
  author={Peter M Winter and Nguyen Minh Dung and Ha Thi Loan and Rachel Kneen and Bridget A. Wills and Le Thi Anh Thu and Deborah House and Nicholas J White and Jeremy J. Farrar and Charles A. Hart and Tom Solomon},
  journal={The Journal of infectious diseases},
  volume={190 9},
BACKGROUND Japanese encephalitis virus (JEV), the mosquito-borne flavivirus, annually causes an estimated 35,000-50,000 encephalitis cases and 10,000-15,000 deaths in Asia, and there is no antiviral treatment. The role played by the immune response in determining the outcome of human infection with JEV is poorly understood, although, in animal models of flavivirus encephalitis, unregulated proinflammatory cytokine responses can be detrimental. METHODS We studied the innate, cellular, and… CONTINUE READING