Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.

@article{Strle2004ProinflammatoryCI,
  title={Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide.},
  author={Klemen Strle and Suzanne R. Broussard and Robert H. McCusker and Wen-hong Shen and Rodney W Johnson and Gregory G Freund and Robert Dantzer and Keith W. Kelley},
  journal={Endocrinology},
  year={2004},
  volume={145 10},
  pages={4592-602}
}
GH and IGF-I control over 80% of postnatal growth. We recently established that TNFalpha impairs the ability of IGF-I to increase protein synthesis and promote expression of myogenin in myoblasts. Here we extend these results by showing that ceramide, a second messenger in both TNFalpha and IL-1beta receptor signaling pathways, is a key downstream sphingosine-based lipid that leads to IGF-I resistance. A cell-permeable ceramide analog, C2-ceramide, inhibits IGF-I-induced protein synthesis by 65… CONTINUE READING

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