Proinflammatory cytokine gene polymorphisms in Behçet's disease.

  title={Proinflammatory cytokine gene polymorphisms in Behçet's disease.},
  author={Aliakbar Amirzargar and Farhad Shahram and Enayat Nikoopour and Nima Attaran Rezaei and Keyvan Saeedfar and Naghmeh Ziaei and Fereydoun Davatchi},
  journal={European cytokine network},
  volume={21 4},
Behçet's disease (BD) is a chronic, systemic disease, characterized by oral and genital lesions, and ocular inflammation. There is evidence indicating altered levels of proinflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) in patients with BD. This study involved 150 patients with BD and 140 healthy controls, and investigated the role of proinflammatory cytokine gene polymorphisms in the disease. The frequency of the TNF-α (-238) G/G genotype was… CONTINUE READING