Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications.

@article{Scherberich2003ProinflammatoryBM,
  title={Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications.},
  author={J{\"u}rgen E. Scherberich},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2003},
  volume={41 10},
  pages={459-64}
}
Although peripheral blood monocytes are heterogeneous, they all express the CD14 molecule, a multifunctional receptor, and part of the toll-like membrane receptor complex. In healthy persons, a minor subset (8%) coexpresses CD14 and CD16, a low affinity Fc-gamma type III receptor. This subpopulation shows characteristics of tissue macrophages and expands greatly in acute and chronic infections, systemic inflammatory syndromes, hyperlipidedemia, AIDS and renal failure. CD14+/CD16+ monocytes (Mo… CONTINUE READING

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