Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature.

  title={Proinflammatory and vasoactive effects of Abeta in the cerebrovasculature.},
  author={Kirk P Townsend and Demian F. Obregon and Amita N Quadros and Natasha Patel and Ch Volmar and Daniel Paris and Mike Mullan},
  journal={Annals of the New York Academy of Sciences},
Abeta peptides are thought to be critical molecules in the pathophysiology of Alzheimer's disease (AD) and are the major protein constituents of senile plaques. In most AD cases, Abeta peptides also form some deposits in the cerebrovasculature, leading to cerebral amyloid angiopathy and hemorrhagic stroke. Regional cerebral hypoperfusion is one of the earlier clinical manifestations in both the sporadic and familial forms of AD. In addition, a variety of vascular risk factors of different… CONTINUE READING


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