Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as Prognostic Markers in Mammary Tumors.

@article{Martins2016ProinflammatoryAA,
  title={Proinflammatory and Anti-Inflammatory Cytokines Mediated by NF-κB Factor as Prognostic Markers in Mammary Tumors.},
  author={Gustavo Rodrigues Martins and Gabriela Bottaro Gelaleti and Marina Gobbe Moschetta and Larissa Bazela Maschio-Signorini and Debora Ap Pires de Campos Zuccari},
  journal={Mediators of inflammation},
  year={2016},
  volume={2016},
  pages={
          9512743
        }
}
Inflammation results in the production of cytokines, such as interleukin- (IL-) 4 and IL-10 with immunosuppressive properties or IL-6 and TNF-α with procarcinogenic activity. Furthermore, NF-κB is the major link between inflammation and tumorigenesis. This study verified the interaction between active inflammatory cytokines in the tumor microenvironment and serum of female dogs with mammary tumors and their correlation with the clinicopathological characteristics and overall survival… CONTINUE READING
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