Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity.

@article{Das2013ProinflammatoryAL,
  title={Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity.},
  author={Suvarthi Das and Ashutosh Kumar and Ratanesh Kumar Seth and Erik J. Tokar and Maria B. Kadiiska and Michael P. Waalkes and Ronald Paul Mason and Saurabh Chatterjee},
  journal={Toxicology and applied pharmacology},
  year={2013},
  volume={269 3},
  pages={297-306}
}
Today's developed world faces a major public health challenge in the rise in the obese population and the increased incidence in fatty liver disease. There is a strong association among diet induced obesity, fatty liver disease and development of nonalcoholic steatohepatitis but the environmental link to disease progression remains unclear. Here we demonstrate that in obesity, early steatohepatitic lesions induced by the water disinfection byproduct bromodichloromethane are mediated by… CONTINUE READING
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