Proinflammation of aging central arteries: a mini-review.

  title={Proinflammation of aging central arteries: a mini-review.},
  author={Mingyi Wang and Robert E. Monticone and Edward G. Lakatta},
  volume={60 6},
Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. an increase in local angiotensin II signaling that induces an inflammatory phenotypic shift of endothelial and… CONTINUE READING