Prohormone convertase-1 is essential for conversion of chromogranin A to pancreastatin.

@article{Udupi1999ProhormoneCI,
  title={Prohormone convertase-1 is essential for conversion of chromogranin A to pancreastatin.},
  author={Vidyavathi Udupi and Heung Man Lee and Alexander Kurosky and George H. Greeley},
  journal={Regulatory peptides},
  year={1999},
  volume={83 2-3},
  pages={123-7}
}
The purpose of this study was to test the hypothesis that the endoprotease, prohormone convertase-1 (PC-1), is involved in the processing of the precursor protein chromogranin A (CGA) to a smaller peptide called pancreastatin (PST). A human pancreatic carcinoid cell line (BON) that expresses PC-1, CGA and PST was stably transfected with antisense PC-1 mRNA… CONTINUE READING