Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

@article{Lucas2013ProhibitinsAT,
  title={Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.},
  author={Christopher R. Lucas and Hector M. Cordero-Nieves and Robert S. Erbe and Jaclyn W. McAlees and Sumeena Bhatia and Richard J Hodes and Kerry S. Campbell and Virginia M. Sanders},
  journal={Journal of immunology},
  year={2013},
  volume={190 2},
  pages={723-36}
}
CD86 engagement on a CD40L/IL-4-primed murine B cell activates signaling intermediates that promote NF-κB activation to increase Oct-2 and mature IgG1 mRNA and protein expression, as well as the rate of IgG1 transcription, without affecting class switch recombination. One of the most proximal signaling intermediates identified is phospholipase Cγ2, a protein reported to bind tyrosine residues, which are absent in the cytoplasmic domain of CD86. Using a proteomics-based identification approach… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
6 Citations
73 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 73 references

A Novel Role for CD 86 Signaling / the CD 86 Signaling Complex in Chronic Lymphocytic Leukemia

  • V. M. Sanders.
  • 2012

Prohibitins and the Cytoplasmic Domain of CD 86 Cooperate to Mediate CD 86 Signaling in B Lymphocytes

  • V. M. Sanders
  • 2012

Similar Papers

Loading similar papers…