Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells.

@article{Peng2006ProhibitinIA,
  title={Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells.},
  author={Xinjian Peng and Rajeshwari R. Mehta and Sheng Wang and S Guruprasad Chellappan and Rajendra G. Mehta},
  journal={Cancer research},
  year={2006},
  volume={66 14},
  pages={7361-9}
}
Previously, we showed that N-methyl-N-nitrosourea-transformed MCF12F breast epithelial cells exhibited differential expression of several genes, including up-regulation of prohibitin and elevated sensitivity to a relatively noncalcemic vitamin D analogue, 1alpha-hydroxyvitamin D5 [1alpha(OH)D5]. In this report, we evaluated the functional significance of prohibitin in relation to the cellular response to vitamin D. The in silico screening for putative transcription factor binding sites… CONTINUE READING

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2 Excerpts

Characteriza - tion of the condensin component Cnap 1 and protein kinase Melk as novel E 2 F target genes down - regulated by 1 , 25dihydroxyvitamin D 3

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