Prohibitin facilitates cellular senescence by recruiting specific corepressors to inhibit E2F target genes.

Abstract

Prohibitin is a growth regulatory gene that has pleiotropic functions in the nucleus, mitochondria, and cytoplasmic compartments. Earlier studies had proposed a role for prohibitin in modulating cellular senescence, but the underlying mechanisms remain unknown. Here we show that senescence induced by DNA-damaging agents causes the localization of prohibitin… (More)

Topics

  • Presentations referencing similar topics