Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells

@inproceedings{Kathiria2012Prohibitin1M,
  title={Prohibitin 1 Modulates Mitochondrial Stress-Related Autophagy in Human Colonic Epithelial Cells},
  author={Arwa S. Kathiria and Lindsay D. Butcher and L A Feagins and Rhonda F Souza and Clement Richard Boland and Arianne L. Theiss},
  booktitle={PloS one},
  year={2012}
}
INTRODUCTION Autophagy is an adaptive response to extracellular and intracellular stress by which cytoplasmic components and organelles, including damaged mitochondria, are degraded to promote cell survival and restore cell homeostasis. Certain genes involved in autophagy confer susceptibility to Crohn's disease. Reactive oxygen species and pro-inflammatory cytokines such as tumor necrosis factor α (TNFα), both of which are increased during active inflammatory bowel disease, promote cellular… CONTINUE READING