Prohibitin: Potential role in senescence, development, and tumor suppression

@article{McClung1995ProhibitinPR,
  title={Prohibitin: Potential role in senescence, development, and tumor suppression},
  author={J. Keith McClung and Eldon Ralph Jupe and X-T. Liu and Robert T. Dell'orco},
  journal={Experimental Gerontology},
  year={1995},
  volume={30},
  pages={99-124}
}
Identification and Analysis of Prohibitin in B16 Mouse Melanoma Cells
TLDR
This work validated the initial findings reported using this cell line and 2D gel electrophoresis, as well as attempt to identify, isolate, and analyze prohibitin using mass spectrometry in order to determine if in its function within the cell, prohibitin was in any way being modified.
Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.
TLDR
The data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging and show that the mammalian prohibitins are present in the inner mitochondrial membrane and always bound to each other, with no free protein detectable.
Capstones 1-1-2008 Identification and Analysis of Prohibitin in B 16 Mouse Melanoma Cells
TLDR
This work validated the initial findings reported using this cell line and 2D gel electrophoresis, as well as attempt to identify, isolate, and analyze prohibitin using mass spectrometry in order to determine if in its function within the cell, prohibitin was in any way being modified.
Prohibitins Are Required for Cancer Cell Proliferation and Adhesion
TLDR
It is shown that prohibitin proteins are necessary for the proliferation of cancer cells and sustaining cancer cell propagation and survival and loss of prohibitins did lead to the degradation of the fusion protein OPA1 and, in certain cancer cell lines, to a reduced capability to exhibit anchorage-independent growth.
Silencing a prohibitin alters plant development and senescence.
TLDR
The data indicate that prohibitins play a key role in plant development and senescence.
The Prohibitins: emerging roles in diverse functions
TLDR
There is now compelling evidence that both prohibitins are localized in the nucleus and can modulate transcriptional activity by interacting with various transcription factors, including the steroid hormone receptors, either directly or indirectly.
Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.
TLDR
The results show that most (80%) of the cell lines derived from breast tumors have a common prohibitin genotype, suggesting that they belong to the same group of immortalized cells, group B, and the prohibitin 3'UTR exhibits the characteristics of a trans-acting regulatory RNA (riboregulator).
Roles of Prohibitin in Growth Control and Tumor Suppression in Human Cancers
TLDR
Through the application of new molecular technologies, additional novel functions of prohibitin have been revealed, demonstrating diverse and essential roles of this highly-conserved protein in regulating cell growth.
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References

SHOWING 1-10 OF 79 REFERENCES
Prohibitin expression during cellular senescence of human diploid fibroblasts.
TLDR
Results suggest that prohibitin is similar to the retinoblastoma gene product whose anti-proliferative activity remains active in older cells because it is not post-synthetically modified.
Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.
TLDR
Results indicate that senescence of both WS and normal HDF is accompanied by overexpression of similar sets of diverse genes which may play a role in the senescent arrest of cellular replication and in the genesis of WS, normal biological aging, and attendant diseases.
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells.
TLDR
The cloning and analysis of cDNA for prohibitin reveals that the prohibitin gene appears to be the mammalian analog of Cc, a Drosophila gene that is vital for normal development.
The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.
TLDR
DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or developed in patients 35 years old or younger, identified 4 cases of somatic mutation.
The human prohibitin (PHB) gene family and its somatic mutations in human tumors.
Five cosmid clones, isolated by procedures to screen genomic libraries for homologous variants of the human prohibitin gene (PHB), were analyzed to determine their genomic structures. Four of these
Absence of prohibitin gene mutations in human epithelial ovarian tumors.
TLDR
Results demonstrate that this region of the prohibitsin gene is not mutated in epithelial ovarian cancers and suggest that the prohibitin gene does not play a role in ovarian carcinogenesis.
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