Prohibitin, an antiproliferative protein, is localized to mitochondria

@article{Ikonen1995ProhibitinAA,
  title={Prohibitin, an antiproliferative protein, is localized to mitochondria},
  author={Elina Ikonen and Klaus Fiedler and Robert G. Parton and Kai Simons},
  journal={FEBS Letters},
  year={1995},
  volume={358}
}
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189 Citations
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189 Citations

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Identification and Analysis of Prohibitin in B16 Mouse Melanoma Cells
TLDR
This work validated the initial findings reported using this cell line and 2D gel electrophoresis, as well as attempt to identify, isolate, and analyze prohibitin using mass spectrometry in order to determine if in its function within the cell, prohibitin was in any way being modified.
Prohibitins and the functional compartmentalization of mitochondrial membranes
Prohibitins constitute an evolutionarily conserved and ubiquitously expressed family of membrane proteins that are essential for cell proliferation and development in higher eukaryotes. Roles for…
Research Progress in the Structure and Functions of Prohibitin
Role of prohibitins for proteolysis in yeast and murine mitochondria
TLDR
The results presented in this work suggest that prohibitins do not play a role as chaperones for the stabilization of mitochondrial proteins, rather, prohibitins function by binding to the mAAA protease in a nucleotide independent manner and presumably modulating the accessibility of substrate to the protease or the activity of the prote enzyme.
Prohibitins in human diseases: diagnostic and therapeutic applications
TLDR
Recent experimental data linking the impairment of the different functions of Prohibitin with the onset of important human pathologies, such as cancer, chronic inflammation and drug-induced toxicity are reviewed to highlight how Prohibitins could represent promising candidate targets for the development of novel therapeutic approaches.
Prohibitin: a potential therapeutic target in tyrosine kinase signaling
TLDR
The opinion is concluded that prohibitin can be used as a potential target for tyrosine kinase signal transduction-targeting therapy, including in insulin, growth factors, and immune signaling pathways.
Prohibitin and the senescent phenotype
Prohibitin and prohibitone are contained in high-molecular weight complexes and interact with alpha-actinin and annexin A2.
Prohibitin function within mitochondria: essential roles for cell proliferation and cristae morphogenesis.
Characterization of the plant homologue of prohibitin, a gene associated with antiproliferative activity in mammalian cells
TLDR
Phylogenetic conservation of prohibitin's amino acid sequence and subcellular localization suggests a similar function in plants, yeast and mammals.
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References

SHOWING 1-10 OF 18 REFERENCES
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells.
TLDR
The cloning and analysis of cDNA for prohibitin reveals that the prohibitin gene appears to be the mammalian analog of Cc, a Drosophila gene that is vital for normal development.
Cell cycle activity and expression of prohibitin mRNA
TLDR
It is suggested that endogenous prohibitin contributes to the control of the G1 to S transition in cycling cells in a complex manner, which involves both a transcriptional and posttranslational mechanism.
Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells.
TLDR
It is proposed that in vivo the CHAPS and Triton complexes form part of a sorting platform that mediates protein segregation and delivery to the apical cell surface.
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin‐related protein.
TLDR
Three newly discovered intracellular proteins of 32, 37 and 41 kDa molecular mass are described, that are non‐covalently associated with mIgM, but not withmIgD, and could explain the different biological events elicited after engagement of each receptor.
A chemically synthesized pre‐sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers.
TLDR
It is suggested that Amphiphilic helicity appears to be a general feature of mitochondrial pre‐sequences that plays a crucial role in transporting proteins into mitochondria.
Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism.
The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.
TLDR
DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or developed in patients 35 years old or younger, identified 4 cases of somatic mutation.
Sequence and expression of the Cc gene, a member of the dopa decarboxylase gene cluster of Drosophila: possible translational regulation.
TLDR
The Cc message contains several open reading frames 5' to the large open reading frame responsible for the lethal complementation group, suggesting that expression of Cc function may be regulated translationally.
Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver.
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.
TLDR
Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide immunogens whose sequences are derived from that of the human c-myc gene product, and all six antibodies recognize immunoblotted p62c- myc.
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