Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis.

@article{Miura1997ProgressiveTS,
  title={Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis.},
  author={Norimasa Miura and Izumi Horikawa and Arata Nishimoto and Hiroshi Ohmura and Haruo Ito and Setsuo Hirohashi and Jerry W Shay and Mitsuo Oshimura},
  journal={Cancer genetics and cytogenetics},
  year={1997},
  volume={93 1},
  pages={56-62}
}
Telomeres shorten progressively with age in normal somatic cells in culture and in vivo. The maintenance of telomere length is assumed to be an obligatory step in the progression and immortalization of most human tumor cells. To understand the role of telomere dynamics in the development of hepatocellular carcinoma (HCC), we examined the length of terminal restriction fragment (TRF), as an indicator for telomere length, in HCC and surrounding tissues with chronic active hepatitis (CAH) or liver… CONTINUE READING

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