Progressive supranuclear palsy: loss of choline-acetyltransferase-like immunoreactive neurons in the pontine reticular formation.

@article{Malessa1991ProgressiveSP,
  title={Progressive supranuclear palsy: loss of choline-acetyltransferase-like immunoreactive neurons in the pontine reticular formation.},
  author={S Malessa and Etienne C. Hirsch and Pascale Cervera and France Javoy-Agid and Charles Duyckaerts and J. J. Hauw and Yves Agid},
  journal={Neurology},
  year={1991},
  volume={41 10},
  pages={1593-7}
}
We performed a quantitative immunocytochemical study using a polyclonal antibody directed against choline acetyltransferase (ChAT) in the lower pontine reticular formation in four control subjects and three patients with progressive supranuclear palsy (PSP). In the normal brains, there was detectable ChAT-like immunoreactivity in the nucleus papillioformis, a precerebellar reticular nucleus, and in the nucleus pontis centralis caudalis. In PSP patients, the mean estimated total number of ChAT… CONTINUE READING