Progressive supranuclear palsy: clinical features and response to treatment in 16 patients.

@article{Jackson1983ProgressiveSP,
  title={Progressive supranuclear palsy: clinical features and response to treatment in 16 patients.},
  author={Jonathan A. Jackson and Joseph Jankovic and Judith O'Malley Ford},
  journal={Annals of neurology},
  year={1983},
  volume={13 3},
  pages={273-8}
}
Among 415 patients with parkinsonism, 16 (3.9%) had findings of progressive supranuclear palsy (PSP). This report reviews the clinical features and response to drug therapy in those 16 patients. Anticholinergic drugs failed to benefit any of the 5 patients treated, while presynaptic dopaminergic drugs (Sinemet or amantadine) were beneficial in only 5 of 22 patient trials. Alternatively, dopamine agonists (bromocriptine and pergolide) caused improvement in 9 of 14 patient trials despite the fact… CONTINUE READING
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