Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia.

@article{Ho2003ProgressiveSB,
  title={Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia.},
  author={Beng-Choon Ho and Nancy C. Andreasen and Peg Nopoulos and Stephan Arndt and Vincent Magnotta and Michael A Flaum},
  journal={Archives of general psychiatry},
  year={2003},
  volume={60 6},
  pages={585-94}
}
BACKGROUND Many studies have shown that structural brain abnormalities in schizophrenia are already present by the time of index evaluation of first-episode patients. However, whether these abnormalities progressively worsen during the subsequent course of the disorder remains unresolved. METHODS To study the longitudinal progression of structural brain abnormalities, high-resolution multispectral magnetic resonance images obtained on 73 recent-onset schizophrenic patients and 23 controls… CONTINUE READING
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