Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein.

@article{Liu2010ProgressiveRP,
  title={Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall protein.},
  author={Yan Liu and Lan Mo and David S. Goldfarb and Andrew P. Evan and Fengxia Liang and Saeed R. Khan and John Charles Lieske and Xue-Ru Wu},
  journal={American journal of physiology. Renal physiology},
  year={2010},
  volume={299 3},
  pages={F469-78}
}
Mammalian urine contains a range of macromolecule proteins that play critical roles in renal stone formation, among which Tamm-Horsfall protein (THP) is by far the most abundant. While THP is a potent inhibitor of crystal aggregation in vitro and its ablation in vivo predisposes one of the two existing mouse models to spontaneous intrarenal calcium crystallization, key controversies remain regarding the role of THP in nephrolithiasis. By carrying out a long-range follow-up of more than 250 THP… CONTINUE READING
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