Progressive-ratio performance maintained by drug infusions: Comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine

@article{Griffiths1978ProgressiveratioPM,
  title={Progressive-ratio performance maintained by drug infusions: Comparison of cocaine, diethylpropion, chlorphentermine, and fenfluramine},
  author={Roland R. Griffiths and Joseph V. Brady and J. Snell},
  journal={Psychopharmacology},
  year={1978},
  volume={56},
  pages={5-13}
}
Cocaine, diethylpropion, chlorphentermine, and fenfluramine were compared on a drug-maintained progressive-ratio procedure in baboons. Intravenous infusions of drug were contingent on completion of a fixed-ratio response requirement (fixed number of lever-press responses) with a 3-h time-out period following each infusion. Prior to testing each dose of drug, stable self-infusion performance was first established with 0.4 mg/kg cocaine when the fixed-ratio requirement was 160. Subsequently, a… CONTINUE READING

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Drug-maintained performance and the analysis of stimulant reinforcing effects

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1 Excerpt

A comparison of cocaine and diethylpropion under the different schedules of drug presentation

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Chlorphentermine: absence of amphetamine-like profile in man [Abstr.

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