Progressive postnatal motoneuron loss in mice lacking GDF-15.

  title={Progressive postnatal motoneuron loss in mice lacking GDF-15.},
  author={Jens Strelau and Adam Strzelczyk and Patricia Rusu and Gerald Bendner and Stefan Wiese and Francesca Diella and Amy L. Altick and Christopher S von Bartheld and Ruediger Klein and Michael Sendtner and Klaus Unsicker},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 43},
Growth/differentiation factor-15 (GDF-15) is a widely expressed distant member of the TGF-beta superfamily with prominent neurotrophic effects on midbrain dopaminergic neurons. We show here that GDF-15-deficient mice exhibit progressive postnatal losses of spinal, facial, and trigeminal motoneurons. This deficit reaches a approximately 20% maximum at 6 months and is accompanied by losses of motor axons and significant impairment of rotarod skills. Similarly, sensory neurons in dorsal root… CONTINUE READING