Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice

@article{Roux2010ProgressiveND,
  title={Progressive noradrenergic deficits in the locus coeruleus of Mecp2 deficient mice},
  author={Jean-Christophe Roux and Nicolas Panayotis and Emmanuelle Dura and Laurent Villard},
  journal={Journal of Neuroscience Research},
  year={2010},
  volume={88}
}
Methyl‐CpG binding protein 2 (MeCP2) is a transcriptional regulator. Mutations in this gene cause a wide range of neurological disorders. Mecp2 deficiency has been previously associated to catecholaminergic dysfunctions leading to autonomic defects in the brainstem and the sympathoadrenergic system of the mouse. The present study was undertaken to determine if the locus coeruleus (LC), the main noradrenergic cell group of the brain, is affected. Using real type PCR, we found a reduction of the… Expand
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