Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice
@article{Cristofanilli2014ProgressiveMS, title={Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice}, author={Massimiliano Cristofanilli and Hannah Rosenthal and Barbara Cymring and Daniel Gratch and Benjamin Pagano and Boxun Xie and Saud A Sadiq}, journal={Experimental Neurology}, year={2014}, volume={261}, pages={620-632} }
18 Citations
Inflammatory mechanisms underlying cortical injury in progressive multiple sclerosis
- Biology, Medicine
- 2020
A better understanding of the interplay between peripheral immune and CNS resident cells is not only relevant to the concept of the disease process, but also represents a novel target for therapeutic intervention that is more specific to progressive disease biology.
Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis
- BiologyMolecular Neurobiology
- 2017
An update on the current knowledge regarding MS pathogenesis and the role of immune cells, microglia, and oligodendrocytes in MS disease progression and novel methods aiming at stimulating the potential of NSCs for the treatment of MS are provided.
The Role of B Cells in Primary Progressive Multiple Sclerosis
- BiologyFrontiers in Neurology
- 2021
The success of ocrelizumab in reducing confirmed disability accumulation in primary progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates B cells as causal agents in the…
The Role of Antibodies in the Pathogenesis of Multiple Sclerosis
- Biology, MedicineFrontiers in Neurology
- 2020
It is proposed a working hypothesis that circulating B cells and antibodies contribute significantly to intrathecal IgGs, thereby exerting primary and pathogenic effects in MS development.
St. John’s wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells
- Biology, MedicineJournal of immunotoxicology
- 2016
The results indicated that hyperforin and HPE could attenuate EAE autoimmune responses by inhibiting immune cell infiltration and expansion of Treg cell and could eventually be considered as a potential candidate for use in the treatment of MS.
Mechanisms of cell–cell interaction in oligodendrogenesis and remyelination after stroke
- BiologyBrain Research
- 2015
CD133-Positive Membrane Particles in Cerebrospinal Fluid of Patients with Inflammatory and Degenerative Neurological Diseases
- Medicine, BiologyFront. Cell. Neurosci.
- 2017
Elevated levels of membrane particle-associated CD133 are revealed in patients with normal pressure hydrocephalus, parkinsonism as well as relapsing-remitting and SPMS in neuroinflammatory and degenerative diseases.
Epidemiology and treatment of multiple sclerosis in elderly populations
- Medicine, PsychologyNature Reviews Neurology
- 2019
The challenges facing elderly patients with multiple sclerosis are reviewed, the complex, evolving relationship between ageing and MS pathophysiology is described, the lack of evidence for the safety and efficacy of disease-modifying therapies in elderly patients is highlighted, and treatment discontinuation and wellness strategies are discussed.
Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis
- Biology, MedicineMultiple sclerosis
- 2017
Galectin-3 is a possible immunological target molecule of the pathogenic auto-antibodies and contributes to the persistent BBB breakdown in patients with SPMS and may also serve as a novel biomarker for SPMS.
Are PrPCs involved in some human myelin diseases? Relating experimental studies to human pathology
- Biology, MedicineJournal of the Neurological Sciences
- 2015
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