Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice

  title={Progressive multiple sclerosis cerebrospinal fluid induces inflammatory demyelination, axonal loss, and astrogliosis in mice},
  author={Massimiliano Cristofanilli and Hannah Rosenthal and Barbara Cymring and Daniel Gratch and Benjamin Pagano and Boxun Xie and Saud A Sadiq},
  journal={Experimental Neurology},
Inflammatory mechanisms underlying cortical injury in progressive multiple sclerosis
A better understanding of the interplay between peripheral immune and CNS resident cells is not only relevant to the concept of the disease process, but also represents a novel target for therapeutic intervention that is more specific to progressive disease biology.
Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis
An update on the current knowledge regarding MS pathogenesis and the role of immune cells, microglia, and oligodendrocytes in MS disease progression and novel methods aiming at stimulating the potential of NSCs for the treatment of MS are provided.
The Role of B Cells in Primary Progressive Multiple Sclerosis
The success of ocrelizumab in reducing confirmed disability accumulation in primary progressive multiple sclerosis (PPMS) via CD20-targeted depletion implicates B cells as causal agents in the
The Role of Antibodies in the Pathogenesis of Multiple Sclerosis
It is proposed a working hypothesis that circulating B cells and antibodies contribute significantly to intrathecal IgGs, thereby exerting primary and pathogenic effects in MS development.
St. John’s wort and its component hyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells
The results indicated that hyperforin and HPE could attenuate EAE autoimmune responses by inhibiting immune cell infiltration and expansion of Treg cell and could eventually be considered as a potential candidate for use in the treatment of MS.
CD133-Positive Membrane Particles in Cerebrospinal Fluid of Patients with Inflammatory and Degenerative Neurological Diseases
Elevated levels of membrane particle-associated CD133 are revealed in patients with normal pressure hydrocephalus, parkinsonism as well as relapsing-remitting and SPMS in neuroinflammatory and degenerative diseases.
Epidemiology and treatment of multiple sclerosis in elderly populations
The challenges facing elderly patients with multiple sclerosis are reviewed, the complex, evolving relationship between ageing and MS pathophysiology is described, the lack of evidence for the safety and efficacy of disease-modifying therapies in elderly patients is highlighted, and treatment discontinuation and wellness strategies are discussed.
Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis
Galectin-3 is a possible immunological target molecule of the pathogenic auto-antibodies and contributes to the persistent BBB breakdown in patients with SPMS and may also serve as a novel biomarker for SPMS.


Demyelination in severe combined immunodeficient mice by intracisternal injection of cerebrospinal fluid cells from patients with multiple sclerosis: neuropathological investigation
Demyelinating lesions have been observed in severe combined immunodeficient (SCID) mice after intracisternal administration of cerebrospinal fluid cells from patients with multiple sclerosis, and it is revealed that CSFC from 6 of 15 patients at exacerbation of MS caused demyelination.
Transfer of multiple sclerosis into severe combined immunodeficiency mice by mononuclear cells from cerebrospinal fluid of the patients.
  • Y. Saeki, T. Mima, T. Kishimoto
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
Significant evidence is provided of encephalitogenicity of mononuclear cells in CSF from MS patients at the exacerbation stage of the disease and of the mode of the pathogenesis of multiple sclerosis.
Axonal transection in the lesions of multiple sclerosis.
Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Axonal damage in acute multiple sclerosis lesions.
The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.
Axonal changes in chronic demyelinated cervical spinal cord plaques.
The results on the cervical cord combined with other observations support the concept of slow axonal degeneration rather than acute damage as a cause of chronic disability in multiple sclerosis.
Immunological markers in multiple sclerosis
MS is a T cell-mediated CNS-confined chronic inflammatory demyelinating disease in which the ultimate effector cell is the activated macrophage, and reliable disease-traits or state-trait immunological markers for MS have not yet been identified.
[Transfer of multiple sclerosis into SCID mice].
The result of intracisternal injection of CSF cells from two patients at exacerbation together with anti-murine TNF-alpha Ab was performed, and it is observed that effective prevention of transfer of MS into SCID mice is observed, suggesting that MS is a T cell-mediated disease.