Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity.

@article{Gorelik2011ProgressiveML,
  title={Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity.},
  author={Leonid Gorelik and Carl E. Reid and Manuela Testa and Margot Brickelmaier and Simona Bossolasco and Annamaria Pazzi and Arabella Bestetti and Paul Carmillo and Ewa Wilson and Michele McAuliffe and Christopher Tonkin and John P. Carulli and Alexey A. Lugovskoy and Adriano Lazzarin and Shamil R. Sunyaev and Kenneth Simon and Paola Cinque},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={204 1},
  pages={103-14}
}
Progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease caused by JC virus (JCV) infection of oligodendrocytes, may develop in patients with immune disorders following reactivation of chronic benign infection. Mutations of JCV capsid viral protein 1 (VP1), the capsid protein involved in binding to sialic acid cell receptors, might favor PML onset. Cerebrospinal fluid sequences from 37/40 PML patients contained one of several JCV VP1 amino acid mutations, which were also… CONTINUE READING
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