Progressive multifocal leukoencephalopathy: clinical description and demonstration of the causal agent.


A 40 year old man with AIDS had memory deficit and visual impairment. The brain magnetic resonance images showed abnormalities in the white matter not enhanced with gadolinium. JC-virus DNA was detected in the cerebrospinal fluid. He died after a few weeks of progressive neurologic deterioration. Histologic examination showed changes compatible with… (More)


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