Progressive multifocal leukoencephalopathy: a review of the pathology and pathogenesis.

  title={Progressive multifocal leukoencephalopathy: a review of the pathology and pathogenesis.},
  author={Allen J. Aksamit},
  journal={Microscopy research and technique},
  volume={32 4},
Progressive multifocal leukoencephalopathy is an important viral opportunistic infection of oligodendrocytes leading to direct demyelination. Virus is likely disseminated to the brain via the blood. However, the timing of that dissemination with relationship to clinical disease is unknown. Important clues about viral pathogenesis have been learned by applying molecular in situ techniques to diseased brain. The oligodendrocyte is the primary target for JC virus infection, and its death is the… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations

Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation • 2017
View 1 Excerpt

A case of progressive multifocal leukoencephalopathy in a patient with sarcoidosis.

QJM : monthly journal of the Association of Physicians • 2012
View 1 Excerpt

Progressive multifocal leukoencephalopathy.

Current treatment options in neurology • 2008
View 9 Excerpts

Similar Papers

Loading similar papers…