Progressive multifocal leukoencephalopathy: a review of the pathology and pathogenesis.

@article{Aksamit1995ProgressiveML,
  title={Progressive multifocal leukoencephalopathy: a review of the pathology and pathogenesis.},
  author={Allen J. Aksamit},
  journal={Microscopy research and technique},
  year={1995},
  volume={32 4},
  pages={302-11}
}
Progressive multifocal leukoencephalopathy is an important viral opportunistic infection of oligodendrocytes leading to direct demyelination. Virus is likely disseminated to the brain via the blood. However, the timing of that dissemination with relationship to clinical disease is unknown. Important clues about viral pathogenesis have been learned by applying molecular in situ techniques to diseased brain. The oligodendrocyte is the primary target for JC virus infection, and its death is the… CONTINUE READING

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