Progressive methylation during the serrated neoplasia pathway of the colorectum

  title={Progressive methylation during the serrated neoplasia pathway of the colorectum},
  author={Seung Myung Dong and Eui Jin Lee and Eun Seok Jeon and Cheol Keun Park and Hee C Kim},
  journal={Modern Pathology},
Serrated adenoma is a recently described entity characterized by having combined architectural features of hyperplastic polyps and classical adenoma. To understand the role of gene regulation in the progression of the serrated neoplasia pathway, we examined the methylation profiles of the promoter regions of 19 genes, DNA ploidy, and mutator phenotype status. In all, 40 sporadic, classical serrated adenomas were pathologically reviewed and divided into four pathologic groups according to their… CONTINUE READING


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