Progressive metabolic and structural cerebral perturbations after traumatic brain injury: an in vivo imaging study in the rat.

@article{Liu2010ProgressiveMA,
  title={Progressive metabolic and structural cerebral perturbations after traumatic brain injury: an in vivo imaging study in the rat.},
  author={Ying Rui Liu and Lisa Cardamone and R. Edward Hogan and M. C. Gregoire and John Michael Williams and Rod J Hicks and David Binns and Amelia S. Koe and Nigel C. Jones and Damian E. Myers and Terence J. O'Brien and Viviane Bouilleret},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2010},
  volume={51 11},
  pages={1788-95}
}
UNLABELLED Traumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic and structural changes in rat brains were assessed after TBI using serial (18)F-FDG PET and 3-dimensional MRI in vivo. METHODS Rats underwent lateral fluid percussion injury (FPI; n = 16) or a sham procedure (n = 11). PET and MR images were acquired at 1 wk and at 1, 3, and 6 mo after injury. Morphologic changes were assessed using MRI-based regions of interest, and… CONTINUE READING

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