Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.

@article{Levin2006ProgressiveLO,
  title={Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.},
  author={N. Levin and Iris Lavon and Bracha Zelikovitsh and Dana P Fuchs and Felix Bokstein and Yakov Fellig and Tali Siegal},
  journal={Cancer},
  year={2006},
  volume={106 8},
  pages={1759-65}
}
BACKGROUND Loss of heterozygosity (LOH) on chromosomes 1p and 19q has been associated with chemosensitivity and improved prognosis in patients with oligodendrogliomas. The DNA repair enzyme O6-methylguanine DNA methyltransferase (MGMT) may induce resistance to DNA-alkylating agents. Recent studies demonstrated that temozolomide (TMZ), an oral alkylating agent, has efficacy in the treatment of patients with progressive, low-grade oligodendroglioma (LGO). However, to the authors' knowledge… CONTINUE READING

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