Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression.

@article{Rak1994ProgressiveLO,
  title={Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression.},
  author={Janusz Rak and E J Hegmann and Chao Lu and Robert S. Kerbel},
  journal={Journal of cellular physiology},
  year={1994},
  volume={159 2},
  pages={245-55}
}
Tumor progression is frequently associated with changes in responsiveness of tumor cells to paracrine growth factors. A potential major source of such paracrine factors in solid tumors are endothelial cells since this type of cell can constitute a sizeable fraction of the cellular composition of solid tumors. As an initial step to examining the possible effects of endothelial cell-associated growth factors on tumor cell growth, a panel of human melanoma cell lines representative of different… CONTINUE READING

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