Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study.

@article{Shinotoh2000ProgressiveLO,
  title={Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study.},
  author={Hitoshi Shinotoh and Hiroki Namba and Kiyoshi Fukushi and Shin-ichiro Nagatsuka and Noriko Tanaka and Akiyo Aotsuka and Tsuneyoshi Ota and Shuji Tanada and Toshiaki Irie},
  journal={Annals of neurology},
  year={2000},
  volume={48 2},
  pages={194-200}
}
We measured brain acetylcholinesterase activity in 30 patients with Alzheimer's disease (AD) and 14 age-matched controls by positron emission tomography (PET) and using a carbon 11-labeled acetylcholine analogue. Seven AD patients had repeat PET scans. The k3 values were calculated as an index of acetylcholinesterase activity in a three-compartment analysis using the metabolite corrected arterial input function. Twenty-eight of the 30 AD patients (14 each in the early and late onset subgroups… CONTINUE READING

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