Progressive loss of antiemetic efficacy during subsequent courses of chemotherapy.

  title={Progressive loss of antiemetic efficacy during subsequent courses of chemotherapy.},
  author={Miguel Angel Mart{\'i}n and Eduardo Diaz-Rubio and Antonio Cuevas Casado and Sophie Dominguez and Javier M. Sastre},
  journal={European journal of cancer},
  volume={28 2-3},
The maintenance of the antiemetic efficacy of a combined protocol (intravenous methylprednisolone, oral thiethylperazine and oral amitriptyline) during six consecutive courses of adjuvant FAC chemotherapy (5-fluorouracil, doxorubicin, cyclophosphamide) was analysed in 107 female breast cancer patients who completed the six planned courses of treatment. A continuous decrease in complete (no vomiting episodes) and major protection rate (0-2 vomiting episodes) was evident during chemotherapy… CONTINUE READING


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