Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster.

@article{Biessmann1988ProgressiveLO,
  title={Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster.},
  author={Harald Biessmann and J M Mason},
  journal={The EMBO journal},
  year={1988},
  volume={7 4},
  pages={1081-6}
}
Terminal deficiencies at the tip of the X chromosome can be induced at a high frequency (0.2-0.3%) by irradiating Drosophila females carrying a homozygous mutator (mu-2) with low doses of X-rays. These terminal deficiencies are unstable, since over a period of 3 1/2 years DNA sequences were lost from their distal ends at a rate of 75 bp per generation, presumably due to the absence of a complete wild-type telomeric structure. Breakpoints of these deletions in the 5' upstream regulatory region… CONTINUE READING

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