Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies

@article{Kempton2010ProgressiveLV,
  title={Progressive lateral ventricular enlargement in schizophrenia: A meta-analysis of longitudinal MRI studies},
  author={Matthew J. Kempton and Daniel Stahl and Steven C. R. Williams and Lynn E. DeLisi},
  journal={Schizophrenia Research},
  year={2010},
  volume={120},
  pages={54-62}
}
BACKGROUND Lateral ventricular enlargement is one of the most consistent findings in patients with schizophrenia; however whether progressive ventricular dilation occurs during the course of the illness has been controversial. To clarify this we conducted a meta-analysis of longitudinal studies measuring the lateral ventricles in patients with schizophrenia and a control group. METHODS The MEDLINE database was searched from 1980 to 2009 for longitudinal MRI studies of patients with… 
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References

SHOWING 1-10 OF 87 REFERENCES
Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study
TLDR
Although the results are not in disagreement with the neurodevelopmental hypothesis, they do provide strong evidence that in schizophrenia progressive brain reduction occurs even in its chronic stage.
Cerebral ventricular change over the first 10 years after the onset of schizophrenia
TLDR
Heterogeneity in the course of brain change whereby some patients may exhibit active structural brain change only early in their illness or not at all after their firstepisode, while others continue to exhibit ventricular change spanning the decade subsequent to their first episode is suggested.
Brain volume in first-episode schizophrenia
TLDR
Average volumetric changes are close to the limit of detection by MRI methods, indicating whether schizophrenia is a neurodegenerative process that begins at about the time of symptom onset, or whether it is better characterised as a neurodevelopmental process that produces abnormal brain volumes at an early age.
Meta-analysis of regional brain volumes in schizophrenia.
OBJECTIVE The authors' goal was to determine whether patients with schizophrenia differ from comparison subjects in regional brain volumes and whether these differences are similar in male and female
Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia
TLDR
It is suggested that a subtle active brain process may be continuing through the first few years of a schizophrenic illness causing greater than the normal adult cortical deterioration.
Progressive structural brain abnormalities and their relationship to clinical outcome: a longitudinal magnetic resonance imaging study early in schizophrenia.
TLDR
There are ongoing changes in the brains of schizophrenic patients during the initial years after diagnosis despite ongoing antipsychotic drug treatment, and progressive changes seem to be most evident in the frontal lobes and to correlate with functional impairment.
Brain morphology in first-episode schizophrenia: A meta-analysis of quantitative magnetic resonance imaging studies
TLDR
The hypothesis of different patterns of involvement of various cerebral areas over the time course of schizophrenia is supported, as some brain abnormalities are already present in first-episode schizophrenic patients.
Longitudinal volumetric MRI study in first- and multiple-episode male schizophrenia patients
TLDR
The results do not support the hypothesis that schizophrenia leads to progressive volume reduction in these areas, although there may be a subset of patients with morphologically visible disease progression.
Brain volume changes in first-episode schizophrenia: a 1-year follow-up study.
TLDR
The loss of global gray matter in schizophrenia is progressive, occurs at an early stage of the illness, and is related to the disease process and antipsychotic medication.
The timing of brain morphological changes in schizophrenia and their relationship to clinical outcome
TLDR
Findings need further evaluation by serial scans over a longer time period before it can be determined that no progression of brain structural abnormalities is occurring as part of the pathology of schizophrenia, even in a subgroup of patients.
...
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