Progressive increase in antibiotic resistance of gram-negative bacterial isolates. Walter Reed Hospital, 1976 to 1980: specific analysis of gentamicin, tobramycin, and amikacin resistance.


During a five-year period at Walter Reed Army Hospital, Washington, DC, the frequency of aminoglycoside resistance among clinical bacterial isolates increased from less than 1% in 1976 to 13% of all isolates in later years. This resistance was seen among frequently isolated species of gram-negative bacilli isolated from patients throughout the hospital and… (More)


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