Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus.

@article{Torten1991ProgressiveID,
  title={Progressive immune dysfunction in cats experimentally infected with feline immunodeficiency virus.},
  author={Michael Torten and Marco Franchini and Jeffery E. Barlough and Jeanne W. George and Edna Mozes and H. -M. Lutz and Niels C Pedersen},
  journal={Journal of virology},
  year={1991},
  volume={65 5},
  pages={2225-30}
}
Within 6 months of infection with the Petaluma isolate of feline immunodeficiency virus, specific-pathogen-free domestic cats exhibited a decrease in the percentage and number of circulating CD4+ lymphocytes and in the CD4+/CD8+ T-cell ratio, along with a marginally significant depression of pokeweed mitogen-induced lymphocyte proliferation in vitro. There was no loss of responsiveness to concanavalin A during this stage, and the cats were capable of mounting a satisfactory antibody response to… CONTINUE READING
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