Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.

@article{Kopp1992ProgressiveGA,
  title={Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes.},
  author={Jeffrey B Kopp and Mary E. Klotman and Scott H. Adler and Leslie A Bruggeman and Peter Dickie and Nancy J Marinos and Michael A. Eckhaus and Joseph L. Bryant and Abner Louis Notkins and Paul E. Klotman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 5},
  pages={
          1577-81
        }
}
Patients infected with human immunodeficiency virus type 1 (HIV-1) develop a renal syndrome characterized by proteinuria, renal failure, and focal segmental glomerulosclerosis. By using a noninfectious HIV-1 DNA construct lacking the gag and pol genes, three transgenic mouse lines have been generated that develop a syndrome remarkably similar to the human disease. In the present study, we have characterized in detail one of these lines, Tg26. In Tg26 mice, proteinuria was detectable at… CONTINUE READING

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