Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma.

@article{Buckingham2008ProgressiveGC,
  title={Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma.},
  author={Brian P Buckingham and Denise M Inman and Wendi S. Lambert and Ericka N. Oglesby and David J. Calkins and Michael R. Steele and Monica L. Vetter and Nicholas Marsh-Armstrong and Philip J. Horner},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 11},
  pages={2735-44}
}
Glaucoma is characterized by retinal ganglion cell (RGC) pathology and a progressive loss of vision. Previous studies suggest RGC death is responsible for vision loss in glaucoma, yet evidence from other neurodegenerative diseases suggests axonal degeneration, in the absence of neuronal loss, can significantly affect neuronal function. To characterize RGC degeneration in the DBA/2 mouse model of glaucoma, we quantified RGCs in mice of various ages using neuronal-specific nuclear protein (NeuN… CONTINUE READING
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